Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-

Name	Nitromifene
Synonyms	CI628 Nitromifen Nitromifene 1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
CAS	10448-84-7

Molecular Formula	C27H28N2O4
Molar Mass	444.52
Storage Condition	Room Temprature
In vitro study	Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase.

biological activity	Nitromifene is an estrogen receptor (ER) antagonist.
Target	ER

Last Update：2024-04-09 21:04:16

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CAS: 10448-84-7
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QQ: 3008007409

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Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]- Request for Quotation